Lu Jieli, China

Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

• Chief Physician, Professor
  
  Representative Work
• Based on the nationwide, multicenter prospective cohort with long-term follow-up (the 4C Study), the research has systematically quantified over 20 traditional risk factors for diabetes and highlighted the critical role of social determinants in health promotion (Lancet Diabetes & Endocrinology 2020; Diabetes Care 2022; Cell Reports Medicine 2024; BMJ 2024). Comprehensive metabolomic profiling has identified and quantitatively characterized more than 1,000 metabolites, uncovering key metabolic drivers involved in the onset and progression of diabetes and delineating the dynamic metabolic trajectory of disease development (Diabetes Care 2022; Cell Reports Medicine 2023; American Journal of Clinical Nutrition 2024).

• Furthermore, population-specific predictive models based on metabolomic signatures have been developed for precision prevention and risk stratification of diabetes in the Chinese population (Diabetologia 2025; Cell Reports Medicine 2025). In addition, nationwide multicenter randomized controlled trials have been conducted to develop novel precision intervention strategies targeting key risk factors and biomarkers (Med 2024; New England Journal of Medicine 2024).

Lecture：Metabolic Heterogeneity Linking Obesity, Diabetes, and Longevity: Insights from the 4C Study